The Indus Hospital project came into being in 2005 when a committed group of doctors, philanthropists, and businessmen came together to support underprivileged communities by creating a modern, free hospital. It was officially registered on 23 June 2008 as a Guarantee Limited Company under Section 42 of the Companies Ordinance 1984, with its office located in Korangi, Karachi.

The hospital serves the entire city, specifically helping around 3 million people living in areas like Saddar Town, Defence Housing Society, Korangi, and Landhi. Dr. Abdul Bari Khan has been managing the project since 2007. Due to the increasing number of patients, the hospital plans to expand from 150 to 1800 beds over the next 10 years. The goal of Indus Hospital is to provide free, comprehensive medical care to patients, aiming to build a large hospital that offers a full range of services to meet the growing demand.